Shared host genetic landscape of respiratory viral infection

• DOI: 10.1073/pnas.2414202122
• Publication Date: 2025-05-15T15:05:21Z
• Authors: Leah B. Soriaga; Dale R. Balce; Istvan Bartha; Arnold Park; Emily Wong; Michael McAllaster; Elizabeth A. Mueller; Ona Barauskas; Esteban Carabajal; Beatriz Kowalski; Sooyoung Lee; Gary Lo; Tara F. Mahoney; Matteo Metruccio; Anna Sahakyan; Logeshwaran Somas...; Tod Steinfeld; Lisha Wang; Laura Wedel; Samantha S. Yim; Li Yin; Jiayi Zhou; Zach Newby; Winston Tse; Johannes Grosse; Herbert W. Virgin; Seungmin Hwang; Amalio Telenti
• Keywords: Rhinovirus; Coronavirus

Respiratory viruses represent a major global health burden. Although these have different life cycles, they may depend on common host genetic factors, which could be targeted by broad-spectrum host-directed therapies. We used genome-wide CRISPR screens and advanced data analytics to map network of genes that support infection nine human respiratory [influenza A virus, parainfluenza rhinovirus, syncytial coronavirus (HCoV)-229E, HCoV-NL63, HCoV-OC43, Middle East syndrome–related coronavirus, severe acute 2]. explored shared pathways using knowledge graphs inform pharmacological targets. selected validated STT3A/B proteins the N-oligosaccharyltransferase complex as targets antiviral small molecules. Our work highlights commonalities viral dependencies feasibility this information develop agents.