AM(1), THE FIRST GENETIC MARKER OF HUMAN IMMUNOGLOBULIN A
Male
Isoantigens
Black People
Immunoglobulins
White People
Pedigree
3. Good health
Black or African American
Genetics, Population
Asian People
Gene Frequency
Japan
Humans
Female
gamma-Globulins
Saliva
Molecular Biology
Genes, Dominant
DOI:
10.1073/pnas.64.4.1211
Publication Date:
2006-05-31T06:17:31Z
AUTHORS (2)
ABSTRACT
The genetic markers of human immunoglobulins have significantly contributed to the understanding of the molecular biology of antibody synthesis. Like the Gm markers of IgG, the first genetic marker of serum IgA, a major immunoglubulin of exocrine secretions, has now been defined and termed Am(1). It is inherited as a Mendelian dominant trait and is independent of the Gm and Inv allotypes. Am(1) is localized in the α-chains of the γA
2
subclass and is independent of the serum γA
2
levels. Its polymorphism makes it suitable for studies in population genetics and the molecular biology of IgA globulin.
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