AM(1), THE FIRST GENETIC MARKER OF HUMAN IMMUNOGLOBULIN A

Male Isoantigens Black People Immunoglobulins White People Pedigree 3. Good health Black or African American Genetics, Population Asian People Gene Frequency Japan Humans Female gamma-Globulins Saliva Molecular Biology Genes, Dominant
DOI: 10.1073/pnas.64.4.1211 Publication Date: 2006-05-31T06:17:31Z
ABSTRACT
The genetic markers of human immunoglobulins have significantly contributed to the understanding of the molecular biology of antibody synthesis. Like the Gm markers of IgG, the first genetic marker of serum IgA, a major immunoglubulin of exocrine secretions, has now been defined and termed Am(1). It is inherited as a Mendelian dominant trait and is independent of the Gm and Inv allotypes. Am(1) is localized in the α-chains of the γA 2 subclass and is independent of the serum γA 2 levels. Its polymorphism makes it suitable for studies in population genetics and the molecular biology of IgA globulin.
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