AM(1), THE FIRST GENETIC MARKER OF HUMAN IMMUNOGLOBULIN A

• DOI: 10.1073/pnas.64.4.1211
• Publication Date: 2006-05-31T06:17:31Z
• Authors: G. N. Vyas; H. H. Fudenberg
• Keywords: Mendelian inheritance; Subclass

The genetic markers of human immunoglobulins have significantly contributed to the understanding molecular biology antibody synthesis. Like Gm IgG, first marker serum IgA, a major immunoglubulin exocrine secretions, has now been defined and termed Am(1). It is inherited as Mendelian dominant trait independent Inv allotypes. Am(1) localized in alpha-chains gammaA(2) subclass levels. Its polymorphism makes it suitable for studies population genetics IgA globulin.