Autoantibody to centromere (kinetochore) in scleroderma sera.

• DOI: 10.1073/pnas.77.3.1627
• Publication Date: 2006-05-31T08:11:35Z
• Authors: Y Moroi; C Peebles; M J Fritzler; J Steigerwald; E M Tan
• Keywords: Sclerodactyly; CREST Syndrome; Scleroderma (fungus)

Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of immunofluorescence staining. One these reacted centromeric regions chromosomes. In chromosome spreads, the staining appeared as two small spheres at centromere, resembling kinetochores. The antigenic determinant be a protein or polypeptide tightly bound DNA. autoantibody was reactive centromeres cells derived humans, mice, and Chinese hamsters. present in high frequency calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) scleroderma.