Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

• DOI: 10.1073/pnas.78.10.6476
• Publication Date: 2006-05-31T08:29:08Z
• Authors: Y Hinuma; K Nagata; M Hanaoka; M Nakai; T Matsumoto; K I Kinoshita; S Shirakawa; I Miyoshi
• Keywords: Immunofluorescence; Antigenicity

Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm 1--5% cells a T-cell line, MT-1, from patient with adult leukemia (ATL), which is endemic southwestern Japan. The antigen was not detected other lymphoid cell lines, including six seven B-cell and four non-T non-B lines. did show cross antigenicity that herpesviruses, Epstein--Barr virus, herpes simplex cytomegalovirus, varicella-zoster herpesvirus saimiri, Marek disease virus. proportion antigen-bearing increased by factor approximately 5 on culture presence 5-iodo-2'-deoxyuridine. Antibodies against MT-1 were found all 44 patients ATL examined 32 40 malignant lymphomas (most them had diseases similar to except leukemic peripheral blood). antibodies also 26% healthy adults ATL-endemic areas but only few those ATL-non-endemic areas. On electron microscopy, extracellular type C virus particles pelleted cultured