Deletions in the alpha-globin gene complex in alpha-thalassemic mice.

• DOI: 10.1073/pnas.78.12.7644
• Publication Date: 2006-05-31T08:36:33Z
• Authors: J B Whitney; J Martinell; R A Popp; L B Russell; W F Anderson
• Keywords: Alpha globulin; Pseudogene; Alpha (finance)

Three induced, heritable mutations in the mouse cause alpha-thalassemias. The adult alpha-globin genes on each mutant chromosome are no longer expressed. Embryos heterozygous for one normal and any of three chromosomes also seem to be deficient embryonic alpha-globin-like x-globin, suggesting that x-globin gene is nearby inactivated. A genetic polymorphism a specific EcoRI site or around complex has been used here show mutated deletion includes segment 12-kilobase band which normally carries two genes. comparable part second inferred. Nonetheless, 4.7-kilobase characterized pseudogene still present mutant. These were recovered after triethylenemelamine x-ray treatments.