Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40.

• DOI: 10.1073/pnas.78.7.4480
• Publication Date: 2006-05-31T08:44:37Z
• Authors: J J Cornelis; Z Z Su; D C Ward; J Rommelaere
• Keywords: Simian

The frequency of mutants among the descendants intact parvovirus H-1 was increased when cells human and rat origin were exposed to UV light prior infection. An enhanced mutagenesis could be induced almost same extent in unirradiated by preinfecting them with or simian virus 40 that had been irradiated light. expression an after cell treatment UV-irradiated delayed, transient, dose-dependent, it dependent on de novo protein synthesis.