The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

• DOI: 10.1073/pnas.83.1.130
• Publication Date: 2006-05-31T20:28:33Z
• Authors: O W McBride; D Merry; D Givol
• Keywords: Southern blot

A clone that cross-hybridizes with a mouse p53 probe has been isolated from cDNA library of simian virus 40-transformed human fibroblasts. This cloned was used as to examine DNAs obtained human-rodent somatic cell hybrids have segregated chromosomes. The results show the gene is located on chromosome 17. In addition, Southern analysis prepared cells containing 17 translocation allowed regional localization most distal band short arm this (17p13). Localization 17p13 confirmed by in situ hybridization metaphase spreads probe.