Retinal dopamine and form-deprivation myopia.

• DOI: 10.1073/pnas.86.2.704
• Publication Date: 2006-05-31T11:05:40Z
• Authors: R A Stone; T Lin; A M Laties; P M Iuvone
• Keywords: 3,4-Dihydroxyphenylacetic acid; Sensory deprivation

Investigation of retinal neurochemistry in a well-defined chick model form-deprivation myopia indicated that dopamine and its metabolite 3,4-dihydroxyphenylacetic acid are reduced myopic as compared to control eyes. The reduction is evident only during light adaptation accompanied by decreased rate biosynthesis. To test whether the alteration metabolism related eye growth, agents known interact with receptors were administered locally deprived Remarkably, expected growth axial dimension was reduced, while equatorial not. Therefore may participate pathway linking visual experience postnatal regulation eye's dimension. mechanism for remains unknown.