Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.

• DOI: 10.1073/pnas.88.22.10138
• Publication Date: 2006-05-31T11:50:38Z
• Authors: P Leroy; H Nakshatri; P Chambon
• Keywords: Alpha (finance); Response element; BETA (programming language); Tretinoin

We have characterized the promoter of mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This contains a response element (RARE) that closely resembles RARE is present in RAR-beta promoter. Moreover, RAR-alpha and proximal sequences are similar to each other generate transcripts whose respective start sites located at positions. The consists two directly repeated 5'-GTTCA-3' motifs which all three RARs (alpha, beta, gamma) bind vitro.