Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

• DOI: 10.1073/pnas.88.7.2918
• Publication Date: 2006-05-31T11:56:40Z
• Authors: A P Kuruvilla; R Shah; G M Hochwald; H D Liggitt; M A Palladino; G J Thorbecke
• Keywords: BETA (programming language); Encephalomyelitis

Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute the inflammatory response associated with autoimmune diseases. Transforming growth beta (TGF-beta 1) counteracts many effects of these cytokines has various immunosuppressive properties. In present study, it is shown that microgram amounts TGF-beta 1, injected daily for 1-2 weeks, protect against collagen-induced arthritis (CIA) relapsing experimental allergic encephalomyelitis (REAE), animal models rheumatoid multiple sclerosis, respectively. When administered during induction disease, prevents CIA but only delays onset REAE by 2-3 days. However, when a remission. occurrence relapses in REAE. The results suggest powerful anti-inflammatory effects, mimicking some respects beneficial drugs without discernable adverse effects.