Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

• DOI: 10.1073/pnas.90.22.10421
• Publication Date: 2006-05-31T12:36:02Z
• Authors: E Lai; K L Clark; S K Burley; J E Darnell
• Keywords: Hepatocyte nuclear factors; Transcription

A family of transcription factors, first identified as hepatocyte nuclear factors (HNF-3 alpha, -3 beta, and gamma) a homeotic Drosophila mutant, fork head, has been intensively studied for the past 4 years. Important findings have emerged about structure DNA-binding portion proteins well biologic discoveries diversity its implied role in early development.