Identification and preliminary characterization of a protein motif related to the zinc finger.

• DOI: 10.1073/pnas.90.6.2112
• Publication Date: 2006-05-31T12:41:16Z
• Authors: R Lovering; I M Hanson; K L Borden; S Martin; N J O'Reilly; G I Evan; D Rahman; D J Pappin; J Trowsdale; P S Freemont
• Keywords: RING finger domain; PHD finger; Ring finger; Sequence motif; LIM domain; Structural motif; Zinc finger nuclease; Motif (music)

We have identified a protein motif, related to the zinc finger, which defines newly discovered family of proteins. The motif was found in sequence human RING1 gene, is proximal major histocompatibility complex region on chromosome six. propose naming this "RING finger" and it 27 proteins, all putative DNA binding functions. synthesized peptide corresponding examined number properties, including metal binding. provide evidence support suggestion that RING finger domain defined