Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

• DOI: 10.1073/pnas.92.14.6264
• Publication Date: 2006-05-31T13:14:14Z
• Authors: L M Carlsson; J Jonsson; T Edlund; S L Marklund
• Keywords: Dismutase; Hyperoxia

Extracellular superoxide dismutase (EC-SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) is a secreted Cu- and Zn-containing tetrameric glycoprotein, the bulk of which bound to heparan sulfate proteoglycans in interstitium tissues. To test function EC-SOD vivo, mice carrying targeted disruption gene were generated. The null mutant develop normally remain healthy until at least 14 months age. No compensatory induction other SOD isoenzymes or antioxidant enzymes was observed. When stressed by exposure > 99% oxygen, display considerable reduction survival time compared wild-type an earlier onset severe lung edema. These findings suggest that while under normal physiological conditions systems may substitute for loss EC-SOD; when animal these are unable provide adequate protection.