A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene.

• DOI: 10.1073/pnas.92.21.9570
• Publication Date: 2006-05-31T13:21:02Z
• Authors: M Yoshida; J Sakuma; S Hayashi; K Abe; I Saito; S Harada; M Sakatani; S Yamamoto; N Matsumoto; Y Kaneda
• Keywords: Pathogenesis; Platelet-derived growth factor

Interstitial pneumonia is characterized by alveolitis with resulting fibrosis of the interstitium. To determine relevance humoral factors in pathogenesis interstitial pneumonia, we introduced expression vectors into Wistar rats via trachea to locally overexpress lungs. Human interleukin (IL) 6 and IL-6 receptor genes induced lymphocytic without marked fibroblast proliferation. In contrast, overexpression human transforming growth factor beta 1 or platelet-derived B gene only mild apparent cellular infiltration alveoli, respectively. However, both significant proliferation fibroblasts deposition collagen fibrils. These histopathologic changes are partly akin those seen lung tissues from patients pulmonary markedly contrast that mimics pneumonia.