Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

• DOI: 10.1073/pnas.92.5.1784
• Publication Date: 2006-05-31T13:27:59Z
• Authors: A M Cameron; J P Steiner; D M Sabatini; A I Kaplin; L D Walensky; S H Snyder
• Keywords: FKBP; Inositol trisphosphate receptor; Inositol trisphosphate

The immunophilin FK506 binding protein 12 (FKBP12) is associated with and modulates the ryanodine receptor calcium release channel of skeletal muscle. Ryanodine has amino acid homology functional similarity another intracellular Ca2+ channel, inositol 1,4,5-trisphosphate (IP3R). In present study we show that highly purified preparations IP3R contain FKBP12. complex these two proteins disrupted by immunosuppressants rapamycin, both which are known to bind FKBP12 high affinity. Disrupting IP3R-FKBP12 interaction increases flux through IP3R, an effect reversed added appears be physiologically linked regulating its conductance.