Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

• DOI: 10.1073/pnas.93.1.131
• Publication Date: 2002-07-26T14:34:16Z
• Authors: P E Scherer; T Okamoto; M Chun; I Nishimoto; H F Lodish; M P Lisanti
• Keywords: Caveolin; Caveolin 1; Caveolin 3

Caveolin, a 21- to 24-kDa integral membrane protein, is principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related caveolin-2, was identified through microsequencing adipocyte-derived caveolin-enriched membranes; caveolin retermed caveolin-1. Caveolins 1 2 are similar in most respects. mRNAs for both caveolin-1 caveolin-2 abundantly expressed white adipose tissue induced during adipocyte differentiation. Caveolin-2 colocalizes caveolin-1, indicating that also localizes caveolae. However, differ functional interactions G proteins, possibly explaining why -2 coexpressed within single cell.