Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivo.

• DOI: 10.1073/pnas.93.18.9921
• Publication Date: 2002-07-26T14:34:16Z
• Authors: G Buzsáki; M Penttonen; Z Nádasdy; A Bragin
• Keywords: Pyramidal cell; Dendritic spike; Population spike; Subiculum

The invasion of sodium spikes from the soma into dendrites was studied in hippocampal pyramidal cells by simultaneous extracellular and intracellular recordings anesthetized rats somatic dendritic potentials freely behaving animals. During complex-spike patterns, recorded immobile or sleeping animal, successive substantially attenuated. Complex-spike bursts occurred association with population discharge CA3-CA1 (sharp wave field events). Synaptic inhibition reduced amplitude prevented occurrence calcium spikes. These findings indicate that (i) voltage-dependent influx is under control inhibitory neurons (ii) temporal coincidence synaptic depolarization activation conductances backpropagating during sharp may be critical for plasticity intact hippocampus.