Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.

• DOI: 10.1073/pnas.93.21.11786
• Publication Date: 2002-07-26T14:32:33Z
• Authors: R J Mazzaccaro; M Gedde; E R Jensen; H M van Santen; H L Ploegh; K L Rock; B R Bloom
• Keywords: Antigen processing

Cell-mediated immune responses are essential for protection against many intracellular pathogens. For Mycobacterium tuberculosis (MTB), requires the activity of T cells that recognize antigens presented in context both major histocompatibility complex (MHC) class II and I molecules. Since MHC presentation generally antigen to be localized cytoplasmic compartment antigen-presenting cells, it remains unclear how pathogens reside primarily within endocytic vesicles infected macrophages, such as MTB, can elicit specific I-restricted cells. A mechanism is described virulent MTB allows soluble ordinarily unable enter cytoplasm, ovalbumin, through pathway The selective presentation, since infection inhibited ovalbumin. tubercle bacilli viable, dependent upon transporter associated with processing (TAP), which translocates antigenic peptides from cytoplasm into endoplasmic reticulum. process mimicked by Listeria monocytogenes listeriolysin, a pore-forming hemolysin derived it, suggesting may have evolved comparable molecules vacuolar generation protective