Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

• DOI: 10.1073/pnas.93.23.12845
• Publication Date: 2002-07-26T14:40:52Z
• Authors: Wen-Ming Yang; Carla Inouye; Yingying Zeng; David Bearss; Edward Seto
• Keywords: YY1; General transcription factor; Transcription; GATAD2B

YY1 is a mammalian zinc-finger transcription factor with unusual structural and functional features. It has been implicated as positive negative regulatory that binds to the CCATNTT consensus DNA element located in promoters of many cellular viral genes. A cDNA encodes YY1-binding protein possesses sequence homology yeast transcriptional RPD3 identified. Gal4 binding domain–mammalian fusion strongly represses from promoter containing sites. Association between requires glycine-rich region on YY1. Mutations this abolish interaction eliminate repression by These data suggest negatively regulates tethering cofactor mechanism highly conserved human.