Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

• DOI: 10.1073/pnas.93.6.2576
• Publication Date: 2002-07-26T14:43:20Z
• Authors: B Olofsson; K Pajusola; A Kaipainen; G von Euler; V Joukov; O Saksela; A Orpana; R F Pettersson; K Alitalo; U Eriksson
• Keywords: 0301 basic medicine; Vascular Endothelial Growth Factor B; Sequence Homology, Amino Acid; Molecular Sequence Data; Endothelial Growth Factors; Mice; 03 medical and health sciences; Gene Expression Regulation; Animals; Humans; Tissue Distribution; Amino Acid Sequence; Endothelium, Vascular; RNA, Messenger; Cloning, Molecular; Peptides; Sequence Alignment; Cells, Cultured

We have isolated and characterized a novel growth factor for endothelial cells, vascular B (VEGF-B), with structural similarities to (VEGF) placenta factor. VEGF-B was particularly abundant in heart skeletal muscle coexpressed VEGF these other tissues. formed cell-surface-associated disulfide-linked homodimers heterodimerized when coexpressed. Conditioned medium from transfected 293EBNA cells expressing stimulated DNA synthesis cells. Our results suggest that has role angiogenesis cell growth, muscle.