The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cellsin situ

• DOI: 10.1073/pnas.94.12.6307
• Publication Date: 2002-07-26T14:31:39Z
• Authors: Jason Chesney; Michael Bacher; Armin Bender; Richard Bucala
• Keywords: Fibrocyte; CD80

Recent studies have identified a novel population of blood-borne cells, termed fibrocytes, that distinct cell surface phenotype (collagen + /CD13 /CD34 /CD45 ), rapidly enter sites tissue injury, and synthesize connective matrix molecules. We found by flow cytometry purified human fibrocytes express each the known components are required for antigen presentation, including class II major histocompatability complex molecules (HLA-DP, -DQ, -DR), costimulatory CD80 CD86, adhesion CD11a, CD54, CD58. Human induced antigen-presenting cell-dependent T proliferation when cultured with specific this proliferative activity was significantly higher than monocytes nearly as high dendritic cells. Mouse also were to presentation function potent APCs in vitro . pulsed HIV-proteins p24 or gp120 delivered site cutaneous injury migrate proximal lymph nodes specifically prime naive These data suggest play an early important role initiation antigen-specific immunity.