Ligand binding was acquired during evolution of nuclear receptors
Evolution, Molecular
0301 basic medicine
0303 health sciences
03 medical and health sciences
Molecular Sequence Data
Animals
Humans
Receptors, Cytoplasmic and Nuclear
Amino Acid Sequence
Ligands
Sequence Analysis
DOI:
10.1073/pnas.94.13.6803
Publication Date:
2002-07-26T14:31:39Z
AUTHORS (9)
ABSTRACT
The nuclear receptor (NR) superfamily comprises, in addition to ligand-activated transcription factors, members for which no ligand has been identified date. We demonstrate that orphan receptors are randomly distributed the evolutionary tree and there is relationship between position of a given liganded chemical nature its ligand. NRs specific metazoans, as revealed by screen NR-related sequences early- non-metazoan organisms. analysis NR gene duplication pattern during evolution metazoans shows present diversity arose from two waves duplications. Strikingly, our results suggest ancestral was an acquired ligand-binding ability subsequent evolution.
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CITATIONS (290)
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