Ligand binding was acquired during evolution of nuclear receptors

Evolution, Molecular 0301 basic medicine 0303 health sciences 03 medical and health sciences Molecular Sequence Data Animals Humans Receptors, Cytoplasmic and Nuclear Amino Acid Sequence Ligands Sequence Analysis
DOI: 10.1073/pnas.94.13.6803 Publication Date: 2002-07-26T14:31:39Z
ABSTRACT
The nuclear receptor (NR) superfamily comprises, in addition to ligand-activated transcription factors, members for which no ligand has been identified date. We demonstrate that orphan receptors are randomly distributed the evolutionary tree and there is relationship between position of a given liganded chemical nature its ligand. NRs specific metazoans, as revealed by screen NR-related sequences early- non-metazoan organisms. analysis NR gene duplication pattern during evolution metazoans shows present diversity arose from two waves duplications. Strikingly, our results suggest ancestral was an acquired ligand-binding ability subsequent evolution.
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