Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

• DOI: 10.1073/pnas.94.14.7531
• Publication Date: 2002-07-26T14:31:44Z
• Authors: Stephane Hunot; Bernard Brugg; Damien Ricard; Patrick P. Michel; Marie-Paule Muriel; Merle Ruberg; Baptiste A. Faucheux; Yves Agid; Etienne C. Hirsch
• Keywords: Nigrostriatal pathway

Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration dopaminergic neurons Parkinson disease (PD) that have recently been shown to die by apoptosis, but relationship between and apoptosis has not yet elucidated. Activation transcription factor NF-κB is associated with stress-induced several nonneuronal vitro models. To investigate whether it may play a role PD, we looked for translocation cytoplasm nucleus, evidence its activation, melanized mesencephalon human brain five patients idiopathic PD seven matched control subjects. In patients, proportion immunoreactive their nuclei was more than 70-fold A possible nuclear localization mesencephalic such primary cultures rat mesencephalon, where preceded transient production free radicals during induced activation sphingomyelin-dependent signaling pathway C 2 -ceramide. The data this oxidant-mediated apoptogenic transduction mechanism neuronal death PD.