The p53 tumor suppressor targets a novel regulator of G protein signaling

• DOI: 10.1073/pnas.94.15.7868
• Publication Date: 2002-07-26T14:44:19Z
• Authors: Leonard Buckbinder; Susana Velasco-Mi...; Yan Chen; Ningzhi Xu; Randy Talbott; Larry Gelbert; Jizong Gao; Bernd R. Seizinger; J. Silvio Gutkind; Nikolai Kley
• Keywords: ASK1

Heterotrimeric G proteins transduce multiple growth-factor-receptor-initiated and intracellular signals that may lead to activation of the mitogen-activated or stress-activated protein kinases. Herein we report on identification a novel p53 target gene (A28-RGS14) is induced in response genotoxic stress encodes member family regulators signaling (RGS) with proposed GTPase-activating activity. Overexpression A28-RGS14p inhibits both i - q -coupled growth-factor-receptor-mediated kinase pathway mammalian cells. Thus, through induction A28-RGS14, regulate cellular sensitivity growth and/or survival factors acting protein-coupled receptor pathways.