Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

• DOI: 10.1073/pnas.95.13.7556
• Publication Date: 2002-07-26T14:35:50Z
• Authors: Daniel H. Kaplan; Vijay Shankaran; Anand S. Dighe; Elisabeth Stockert; Michel Aguet; Lloyd J. Old; Robert D. Schreiber
• Keywords: Methylcholanthrene; Ratón

This study demonstrates that endogenously produced interferon gamma (IFN-gamma) forms the basis of a tumor surveillance system controls development both chemically induced and spontaneously arising tumors in mice. Compared with wild-type mice, mice lacking sensitivity to either IFN-gamma (i.e., receptor-deficient mice) or all IFN family members Stat1-deficient developed more rapidly greater frequency when challenged different doses chemical carcinogen methylcholanthrene. In addition, IFN-gamma-insensitive than bred onto background deficient p53 tumor-suppressor gene. p53(-/-) also broader spectrum compared alone. Using cells derived from methylcholanthrene-treated we found IFN-gamma's actions be mediated at least partly through its direct effects on cell leading enhanced immunogenicity. The importance generality this is evidenced by finding certain types human become selectively unresponsive IFN-gamma. Thus, an extrinsic mechanism immunocompetent hosts.