Separation of C/EBPα-mediated proliferation arrest and differentiation pathways

• DOI: 10.1073/pnas.96.13.7276
• Publication Date: 2002-07-26T14:40:52Z
• Authors: Christine Müller; Marianna Alunni-F...; Elisabeth Kowenz-...; Xianming Mo; Massimo Tommasino; Achim Leutz
• Keywords: Ccaat-enhancer-binding proteins

Cell proliferation and terminal differentiation are mutually exclusive in most cell lineages. The b-zip transcription factor CCAAT/enhancer-binding protein α (C/EBPα) induces arrest many types, suggesting that both activities linked. Here we show C/EBPα-mediated pathways can be separated by the E7 oncoprotein of “high-risk” human papilloma virus 16. overrides cycle withdrawal without compromising transactivation activity C/EBPα or its ability to participate differentiation. Uncoupling depends on casein kinase II site but not neutralize pocket proteins cyclin-dependent inhibitor p21. Our results suggest a bifurcation pathways.