Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes

• DOI: 10.1073/pnas.96.21.12004
• Publication Date: 2002-07-26T14:38:21Z
• Authors: Enrique Gonzalez; Mike Bamshad; Naoko Sato; Srinivas Mummidi; Rahul Dhanda; Gabriel Catano; Sonia Cabrera; Megan McBride; Xuan-Hien Cao; Gerald Merrill; Peter O’Connell; Donald W. Bowden; Barry I. Freedman; Stephanie A. Ande...; Elizabeth A. Walter; James S. Evans; Kevin T. Stephan; Robert A. Clark; Sanjay Tyagi; Seema S. Ahuja; Matthew J. Dolan; Sunil K. Ahuja
• Keywords: Chemokine receptor CCR5

Genetic variation in CC chemokine receptor 5 ( CCR5 ), the major HIV-1 coreceptor, has been shown to influence transmission and disease progression. However, it is generally assumed that same genotype (or haplotype) similar phenotypic effects different populations. To test this assumption, we used an evolutionary-based classification of haplotypes determine their associated disease-modifying a large well-characterized racially mixed cohort HIV-1-seropositive individuals. We demonstrate spectrum with acceleration or retardation differs between African Americans Caucasians. Also, show there strong interactive effect evolutionary histories. The striking population-specific emphasize importance understanding context which susceptibility genes are expressed.