Nrf2 is essential for protection against acute pulmonary injury in mice

• DOI: 10.1073/pnas.96.22.12731
• Publication Date: 2002-07-26T14:32:33Z
• Authors: Kaimin Chan; Yuet Wai Kan
• Keywords: Butylated hydroxytoluene; Detoxification

Nrf2 is a member of the “cap ‘n’ collar” family transcription factors. These factors bind to NF-E2 binding sites (GCTGAGTCA) that are essential for regulation erythroid-specific genes. expressed in wide range tissues, many which expression phase 2 detoxification −/− mice viable and have normal phenotype under laboratory conditions. The site subset antioxidant response elements sequence GCNNNGTCA. regulatory sequences found on promoters several genes inducible by xenobiotics antioxidants. We report here extremely susceptible administration butylated hydroxytoluene. With doses hydroxytoluene tolerated wild-type mice, succumb from acute respiratory distress syndrome. Gene studies show enzymes altered mice. may prove be good vivo model toxicological studies. As oxidative damage causes DNA breakage, these also useful testing carcinogenic agents.