Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

• DOI: 10.1073/pnas.96.7.4131
• Publication Date: 2002-07-26T14:35:07Z
• Authors: Yasushi Takagi; Akira Mitsui; Akira Nishiyama; Kazuhiko Nozaki; Hiroshi Sono; Yasuhiro Gon; Nobuo Hashimoto; Junji Yodoi
• Keywords: Brain damage; Brain ischemia; Ratón; Stroke

Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments, including regulation of various intracellular molecules via thiol redox control. We produced TRX overexpressing mice confirmed that there were no anatomical physiological differences between wild-type (WT) transgenic (Tg) mice. In the present study we subjected to focal brain ischemia shed light on role ischemic injury. At 24 hr after middle cerebral artery occlusion, infarct areas volume significantly smaller Tg than WT Moreover neurological deficit was ameliorated compared with Protein carbonyl content, a marker cellular protein oxidation, showed less increase did insult. Furthermore, c-fos expression stronger 1 ischemia. Our results suggest transgene decreased neuronal injury state modified by play crucial damage during stroke.