Involvement of decidual Vα14 NKT cells in abortion
Male
Mice, Knockout
Pore Forming Cytotoxic Proteins
0301 basic medicine
0303 health sciences
Membrane Glycoproteins
Perforin
Receptors, Antigen, T-Cell, alpha-beta
Abortion, Induced
Galactosylceramides
Flow Cytometry
Specific Pathogen-Free Organisms
Trophoblasts
3. Good health
Killer Cells, Natural
Mice, Inbred C57BL
Interferon-gamma
Mice
03 medical and health sciences
Pregnancy
Decidua
Animals
Cytokines
Female
DOI:
10.1073/pnas.97.2.740
Publication Date:
2002-07-26T10:32:33Z
AUTHORS (13)
ABSTRACT
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by Vα14/Jα281 and Vβ7 segments, accumulated in the decidua during pregnancy and provoked abortion upon stimulation with α-galactosylceramide (α-GalCer), a specific ligand for Vα14 NKT cells. The α-GalCer-mediated abortion was not observed in Vα14 NKT-, IFN-γ-, tumor necrosis factor α-, or perforin-knock-out mice and appeared to be due to the degeneration of embryonic trophoblasts mediated by the activated Vα14 NKT cells whose perforin-dependent killing and production of IFN-γ and tumor necrosis factor α were essential. The possible role of the decidual Vα14 NKT cells in the pathogenesis of abortion is discussed.
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CITATIONS (141)
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