Involvement of decidual Vα14 NKT cells in abortion

Male Mice, Knockout Pore Forming Cytotoxic Proteins 0301 basic medicine 0303 health sciences Membrane Glycoproteins Perforin Receptors, Antigen, T-Cell, alpha-beta Abortion, Induced Galactosylceramides Flow Cytometry Specific Pathogen-Free Organisms Trophoblasts 3. Good health Killer Cells, Natural Mice, Inbred C57BL Interferon-gamma Mice 03 medical and health sciences Pregnancy Decidua Animals Cytokines Female
DOI: 10.1073/pnas.97.2.740 Publication Date: 2002-07-26T10:32:33Z
ABSTRACT
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by Vα14/Jα281 and Vβ7 segments, accumulated in the decidua during pregnancy and provoked abortion upon stimulation with α-galactosylceramide (α-GalCer), a specific ligand for Vα14 NKT cells. The α-GalCer-mediated abortion was not observed in Vα14 NKT-, IFN-γ-, tumor necrosis factor α-, or perforin-knock-out mice and appeared to be due to the degeneration of embryonic trophoblasts mediated by the activated Vα14 NKT cells whose perforin-dependent killing and production of IFN-γ and tumor necrosis factor α were essential. The possible role of the decidual Vα14 NKT cells in the pathogenesis of abortion is discussed.
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