The Structures of the HC Fragment of Tetanus Toxin with Carbohydrate Subunit Complexes Provide Insight into Ganglioside Binding

• DOI: 10.1074/jbc.275.12.8889
• Publication Date: 2002-07-26T15:04:49Z
• Authors: Paul Emsley; Constantina Fotinou; Isobel Black; Neil F. Fairweather; Ian G. Charles; Colin Watts; Eric Hewitt; Neil W. Isaacs
• Keywords: Ganglioside; Fragment (logic)

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding toxin to gangliosides on cell surface. carboxyl-terminal fragment heavy chain contains ganglioside-binding site, which has not yet been fully characterized. crystal structures native H(C) and soaked with carbohydrates reveal a number sites provide insight possible mode ganglioside binding.