mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is not required for Akt1 activity in human platelets.

• DOI: 10.1074/jbc.a110.202341
• Publication Date: 2011-08-26T15:22:53Z
• Authors: Samantha F. Moore; Roger W. Hunter; Ingeborg Hers
• Keywords: mTORC2

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human PlateletsJournal of Biological ChemistryVol. 286Issue 28PreviewProtein kinase (PKB, Akt) is a Ser/Thr involved the regulation cell survival, proliferation, and metabolism activated by dual phosphorylation on Thr308 activation loop Ser473 hydrophobic motif. It plays contributory role to platelet function, although little known about its regulation. In this study, we investigated mammalian target rapamycin complex (mTORC)-2 Akt using recently identified small molecule ATP competitive mTOR inhibitors PP242 Torin1. Full-Text PDF Open Access VOLUME 286 (2011) PAGES 24553–24560 protein not protein. used throughout article. Because this, title article should read “mTORC2 Complex-mediated (Protein B) Platelets.”