Moloney Leukemia Virus 10 (MOV10) Protein Inhibits Retrovirus Replication

• DOI: 10.1074/jbc.m110.109314
• Publication Date: 2010-03-10T01:18:32Z
• Authors: Xiaojun Wang; Yanxing Han; Ying Dang; William Fu; Tao Zhou; Roger G. Ptak; Yong-Hui Zheng
• Keywords: RNA Helicase A; Infectivity; RNA Silencing

Moloney leukemia virus 10 (MOV10) protein is a superfamily-1 RNA helicase, and it also component of the RNA-induced silencing complex. Recent studies have shown that MOV10 plays an active role in interference pathway. Here, we report inhibits retrovirus replication. When was overexpressed viral producer cells, able to reduce infectivity human immunodeficiency type 1 (HIV-1), simian virus, murine virus. Conversely, when expression reduced by small interfering RNAs, HIV-1 increased. Consistently, T cell line enhanced Furthermore, found interacts with nucleocapsid RNA-dependent manner packaged into virions. It blocks replication at postentry step. In addition, could suppress counteract this cellular resistance. All these results indicate has broad antiretroviral activity can target wide range retroviruses, be actively involved host defense against retroviral infection.