Hypothalamic Ahi1 Mediates Feeding Behavior through Interaction with 5-HT2C Receptor

• DOI: 10.1074/jbc.m111.277871
• Publication Date: 2011-11-29T05:02:14Z
• Authors: Hao Wang; Zhenbo Huang; Liansha Huang; Shaona Niu; Xiurong Rao; Jing Xu; Hui Kong; Jianzhong Yang; Chuan Yang; Donghai Wu; Shihua Li; Xiao-Jiang Li; Tonghua Liu; Guoqing Sheng
• Keywords: 5-HT2C receptor

It is indicated that there are important molecules interacting with brain nervous systems to regulate feeding and energy balance by influencing the signaling pathways of these systems, but relatively few critical players have been identified. In present study, we provide evidence for role Abelson helper integration site 1 (Ahi1) protein as a mediator behavior through interaction serotonin receptor 2C (5-HT2CR), known its in appetite control. First, demonstrated co-localization between hypothalamic Ahi1 5-HT2CR. promoted degradation 5-HT2CR lysosomal pathway. Then, investigated effects fasting on expression Fasting resulted an increased concomitant decreased Knockdown led decrease food intake body weight. Last, found could neuropeptide Y proopiomelanocortin. Taken together, our results indicate mediates modulate