Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein

• DOI: 10.1074/jbc.m114.624965
• Publication Date: 2015-02-21T03:16:06Z
• Authors: Yuanhong Zheng; Fangyuan Zou; Jingjing Wang; Guifang Yin; Vanminh Le; Zhewei Fei; Jianwen Liu
• Keywords: CD47; Cancer Immunotherapy; Thrombospondin 1; Cancer vaccine

Like most of the strategies for cancer immunotherapy, photodynamic therapy-mediated vaccination has shown poor clinical outcomes in application. The aim this study is to offer a glimpse at mechanisms that are responsible failure based on immuno-editing theory and search positive solution. In we found tumor cells were able adapt themselves immune pressure exerted by vaccination. survived exhibited enhanced tumorigenic stem-like phenotypes as well undermined immunogenicity. Viewed whole, immune-selected showed more malignant characteristics ability escape, which might contribute eventual relapse. Thrombospondin-1 signaling via CD47 helped prevent from becoming rendered them vulnerable attack. These findings prove TSP-1/CD47/SIRP-α signal axis important evolution microenvironment immunotherapy identify thrombospondin-1 key with therapeutic benefits overcoming long term relapse, providing new evidence promise