Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity

• DOI: 10.1074/jbc.m114.634568
• Publication Date: 2015-04-14T01:52:31Z
• Authors: Kanakadurga Singer; Nidhi Maley; Taleen Mergian; Jennifer DelProposto; Kae Won Cho; Brian F. Zamarron; Gabriel Martinez-...; Lynn Geletka; Lindsey Muir; Phillip Wachowiak; Chaghig Demirjian; Carey N. Lumeng
• Keywords: Myelopoiesis; Proinflammatory cytokine; Sexual dimorphism

Women of reproductive age are protected from metabolic disease relative to postmenopausal women and men. Most preclinical rodent studies skewed toward the use male mice study obesity-induced dysfunction because a similar protection observed in female mice. How sex differences inflammatory responses contribute these observations is unknown. We have compared contrasted effects high fat diet-induced obesity on glucose metabolism leukocyte activation multiple depots C57Bl/6 With both short term long diet, demonstrated increased weight gain CD11c+ adipose tissue macrophage content with despite degrees adipocyte hypertrophy. Competitive bone marrow transplant that induced preferential contribution hematopoietic cells circulating leukocytes macrophages independent recipient. Sex cell vitro response obesogenic cues were explain results. In summary, this report demonstrates stem cell-autonomous their an amplified males females.Background: Diet-induced leads chronic low grade inflammation production activated associated systemic sexually dimorphic dysfunction.Results: Males enhanced myelopoiesis proinflammatory females.Conclusion: result inflammation.Significance: Given responses, targeted treatment strategies probably required for females. Background: dysfunction. Results: Conclusion: inflammation. Significance: