CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal

• DOI: 10.1074/jbc.m116.749804
• Publication Date: 2016-12-02T01:15:22Z
• Authors: Gospel Enyindah-A...; Yan Li; Wei Xin; Nora G. Singer; Neetu Gupta; John Fung; Feng Lin
• Keywords: Pathogenesis; Peritoneal cavity

Intestinal ischemia/reperfusion (I/R) injury is a relatively common pathological condition that can lead to multi-organ failure and mortality. Regulatory mechanism for this disease poorly understood, although it established circulating pathogenic natural IgM, which primarily produced by B1a cells outside of the peritoneal cavity, are integrally involved. CD6 was originally identified as marker T later found be present on some subsets B in humans; however, whether plays any role intestinal I/R-induced and, if so, underlying mechanisms, remain unknown. Here we report CD6−/− mice were significantly protected from inflammation mucosal damage compared with WT model injury. Mechanistically, selectively expressed B1 bone marrow cavity IgM titers reduced association decreased cell population. Our results reveal an unexpected pathogenesis IR-induced regulating self-renewal cells.