NF-κB-dependent Induction of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas/FasL Is Crucial for Efficient Influenza Virus Propagation

• DOI: 10.1074/jbc.m403258200
• Publication Date: 2004-07-16T18:47:37Z
• Authors: Walter J. Wurzer; Christina Ehrhardt; Stephan Pleschka; Friederike Berber...; Thorsten Wolff; Henning Walczak; Oliver Planz; Stephan Ludwig
• Keywords: Fas ligand

Activation of the transcription factor NF-kappaB is a hallmark infections by viral pathogens including influenza viruses. Because gene expression many proinflammatory and antiviral cytokines controlled this factor, concept emerged that its upstream regulator IkappaB kinase are essential components innate immune response to infectious pathogens. In contrast common view we report here activity promotes efficient virus production. On molecular level due NF-kappaB-dependent induction proapoptotic factors tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) FasL, which enhance propagation in an autocrine paracrine fashion. Thus, acts both proapoptotically provirally context infection.