Reappearance of an 11-year-old sequence in an HIV-1 infected patient during treatment interruption

• DOI: 10.1080/00365540701558706
• Publication Date: 2008-01-11T19:42:52Z
• Authors: Tina Vasehus Madsen; Jan Gerstoft; Claus Nielsen; Louise Bruun Jørg...
• Keywords: Reversion; Viral evolution

HIV-1 from a patient with multi-drug resistant virus was identified as wild type during treatment interruption. The aim of the study to describe how viral population is affected by interruptions and use phylogeny reconstruct evolutionary pattern. 15 samples covering 13 y 2 were analysed in both pol env. found sample second interruption 2002 had not been present dominant since 1994. Phylogeny showed that more closely related sequences than other sampled 2002. This indicated caused recruitment archives rather reversion previously circulating strains. A few weeks after re-initiated treatment, full resistance, indicating subpopulation reselected due higher fitness presence drugs. env CCR5 CXCR4 viruses coexist patient. In conclusion, at all times infection, archived cells can be recruited when surrounding environment changes fit.