The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

• DOI: 10.1080/01480545.2021.1957912
• Publication Date: 2021-07-26T09:34:25Z
• Authors: Muhammed Fatih Doğan; Neşe Başak Türkmen; Aslı Taşlıdere; Yasemin Şahin; Osman Çiftçi
• Keywords: TBARS; Capsaicin; Thiobarbituric acid

The present study aimed to investigate the protective role of capsaicin in a rat model 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced toxicity. Exposure TCDD which is an environmental toxicant causes severe toxic effects animal and human tissues. Therefore, potential effect TCDD-induced organ damage was investigated rats by measuring thiobarbituric acid reactive substances (TBARS) level, superoxide dismutase (SOD) activity, glutathione (GSH) level heart, liver, kidney tissues for oxidant/antioxidant balance. Thirty-two healthy adults (250-300 g weight 3-4 months old) male Wistar albino were randomly distributed into four equal groups (n = 8): Control, CAP, TCDD, + CAP. A dose 2 μg/kg or 25 mg/kg dissolved corn oil orally administered 30 days. results indicated that oxidative stress increasing TBARS decreasing levels GSH, SOD activity rats. However, treatment significantly decreased increased GSH (p < 0.05). In addition, (25 mg/kg) attenuated histopathological alteration associated with As regulates imbalance attenuates alterations tissues, it may be preventing agents