Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP

• DOI: 10.1080/01480545.2022.2069804
• Publication Date: 2022-05-05T04:59:10Z
• Authors: Ashish Dogra; Dilpreet Kour; Abhishek Gour; Mahir Bhardwaj; Swarnendu Bag; Shakti Kumar Dhiman; Ajay Kumar; Gurdarshan Singh; Utpal Nandi
• Keywords: Diclofenac

Diclofenac is a widely prescribed anti-inflammatory drug having cardiovascular complications as one of the main liabilities that restrict its therapeutic use. We aimed to investigate for any role rutin against diclofenac-induced cardiac injury with underlying mechanisms there no such precedent date. The effect (10 and 20 mg/kg) was evaluated upon concomitant oral administration fifteen days diclofenac mg/kg). Rutin significantly attenuated alterations in serum markers (LDH, CK-MB, SGOT), cytokine levels (TNF-α IL-6), oxidative stress (MDA GSH) tissue. Histopathological examination Scanning Electron Microscopy (SEM) findings displayed marked prevent diclofenac-mediated injury. Altered protein expression myocardial (cTnT, FABP3, ANP) apoptotic (Bcl-2 Caspase-3) tissue treatment considerably shielded by treatment. MYL3 unaffected due or also improved gastrointestinal hepatic based on observed ameliorative effects key mediators, markers, histopathology examination, SEM findings. Overall results suggest can protect lowering stress, inhibiting inflammation, reducing apoptosis. Further research work directs toward development phytotherapeutics cardioprotection.