Ulva fasciata, a green alga, attenuates the kidney and liver dysfunctions in rats induced by acetaminophen

• DOI: 10.1080/01480545.2022.2150206
• Publication Date: 2022-12-08T07:58:33Z
• Authors: Nida Sohail; Maria Azam; Hafiza Farhat; Khan Hira; Faizah Urooj; Shamim A. Qureshi; Jehan Ara; Muhammad Shaiq Ali; Syed Ehteshamul-H...
• Keywords: Antipyretic; Acetaminophen; Blood urea nitrogen

Acetaminophen (AAP) is an analgesic–antipyretic drug which considered safe at recommended dose, but its overuse may induce renal and hepatic injuries. Marine macro algae have great potential against drug-induced dysfunctions. The present study described the reno-protective hepato-protective effects of ethanol extract edible green alga Ulva fasciata fractions (n-hexane, chloroform methanol) AAP toxicity. In 1st set experiment, rats were divided into five groups. Of two treatment groups beside three controls, first group was given U. alone second same with AAP. 2nd nine groups, administered n-hexane, methanol respectively while other received individually On 11th day, decapitated after 12 h fasting from both sets, blood samples collected for assessment biochemical parameters kidney tissues used determination oxidants antioxidants. Histopathological also done in tissues. A single dose (600 mg/kg) affected markers including creatinine, urea nitrogen (BUN) enzymes. Ethanolic normalized liver intoxicated rats. reduced glutathione (GSH) altered architecture, improved by ethanolic soluble fraction fasciata. total 14 polyunsaturated fatty acids identified GC-MS assumed these be involved protective activities