Transferrin and Prealbumin Identify Esophageal Cancer Patients with Malnutrition and Poor Prognosis in Patients with Normal Albuminemia: A Cohort Study

• DOI: 10.1080/01635581.2022.2079687
• Publication Date: 2022-06-02T12:14:33Z
• Authors: Hsueh-Chien Chiang; Meng-Ying Lin; Forn-Chia Lin; Nai-Jung Chiang; Yi-Ching Wang; Wu-Wei Lai; Wei-Lun Chang; Bor-Shyang Sheu
• Keywords: Serum Albumin

In this study, we aimed to analyze whether serum prealbumin and transferrin have a higher sensitivity than albumin for detecting malnutrition predicting survival in esophageal cancer patients. A total of 212 patients were prospectively enrolled. Serum albumin, prealbumin, analyzed by enzyme-linked immunosorbent assays. The association nutritional markers with was analyzed. We found that presented 44.5% the patients, while 56.6% unaware their body weight change. area under curve diagnosing largest followed optimal breakpoints 21 mg/dL, 206 4.3 g/dL, respectively, malnutrition. diagnostic 34.1-63.4% single marker increased 80.5% all 3 markers. normal albuminemia (≥ g/dL), low level and/or predicted poor prognosis. Multivariate Cox regression analysis confirmed an independent prognostic factor. conclusion, outperformed identifying Checking three will help early diagnosis enable timely intervention.