(ICORG 05-03): prospective randomized non-inferiority phase III trial comparing two radiation schedules in malignant spinal cord compression (not proceeding with surgical decompression); the quality of life analysis

• DOI: 10.1080/0284186x.2018.1433320
• Publication Date: 2018-02-08T13:31:11Z
• Authors: K. A. Lee; M. Dunne; C. Small; P. J. Kelly; O. McArdle; J. O’Sullivan; D. Hacking; M. Pomeroy; J. Armstrong; M. Moriarty; A. Clayton-Lea; I. Parker; C. D. Collins; P. Thirion
• Keywords: Spinal cord compression

Background: The optimal primary external beam radiation therapy (EBRT) schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. ICORG 05-03 trial assessed if a 10 Gy single fraction was not inferior one with 20 Gray (Gy) in five daily fractions, terms of functional motor outcome, the treatment MSCC patients proceeding surgical decompression. This article reports on two secondary endpoints, Quality life (QoL), according European Organization Research and Treatment Cancer (EORTC) Life Questionnaire Core 30 (QLQ-C30) version 3.0 (EORTC Data Center, Brussels, Belgium) pain control using visual analog scale.Methods: A randomized, parallel group, multicenter phase III conducted by Trials Ireland (formerly All-Ireland Cooperative Oncology Group, ICORG), across hospital sites Northern Ireland. Patients were randomized EBRT or fractions 1:1 ratio. baseline 5-week follow up QoL data are included this analysis.Findings: From 2006 2014, 112 eligible enrolled whom 57 evaluated analysis. After adjusting pre-intervention scores, there no statistically significant difference post-treatment Summary scores (excl. FI QL), between RT schedules at 5 weeks 3 months following EBRT. There relationship pretreatment (p = .002) but pre-treatment scores.Interpretation: Primary radiotherapy significantly improves scores. For most patients, an effective low burden would desirable. should considered group patients.