Prospective randomised phase II trial evaluating adjuvant pelvic radiotherapy using either IMRT or 3-Dimensional planning for endometrial cancer

• DOI: 10.1080/0284186x.2023.2238555
• Publication Date: 2023-07-26T14:41:30Z
• Authors: Killian Nugent; Darragh Browne; Mary Dunne; Lydia O Sullivan; Aoife M. Shannon; Deepti Sharma; Shirley Bradshaw; Orla McArdle; Osama Salib; Naomi Lavan; Charles Gillham
• Keywords: Gastrointestinal Tract; Humans; Female; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Prospective Studies; 3. Good health; Pelvis; Endometrial Neoplasms

To compare the incidence of grade ≥2 gastrointestinal (GI) or genitourinary (GU) toxicity for patients undergoing 3DRT versus IMRT in postoperative setting endometrial cancer.Eligible were post-operatively randomly assigned to one two parallel groups a 1:1 ratio, have their RT delivered using either technique IMRT. The prescription dose was 45 Gy 25 fractions over 5 weeks followed by vaginal vault brachytherapy. Toxicity graded according National Cancer Institute (NCI) Common Terminology Criteria Adverse Events (CTCAE) version (v) 3.0. Fisher's exact tests used test associations between and arm. Differences dosimetric parameters with without tested Mann-Whitney U-tests.84 median age 62 evaluable primary outcome. follow-up 52 months. 14 (35%) participants from arm 15 (34%) experienced acute GI older having statistically higher risk toxicity. 20 (50%) (57%) GU (p = .662). 12 (30%) 17 (39%) .493).Although can reduce normal tissue, this study no benefit outcome seen.