Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study

• DOI: 10.1080/07853890.2023.2274512
• Publication Date: 2023-11-19T14:30:45Z
• Authors: Cuiyun Li; Min Wu; Hong Zhang; Xiaoxue Zhu; Li Fu; Shuo Wang; Mingming Lu; Dafang Zhong; Yanhua Ding
• Keywords: Tolerability; Bioequivalence; Antipyretic

Background Forsythin, an active compound from Forsythiae Fructus, has the potential to treat common cold and influenza through its antipyretic-analgesic, anti-inflammatory antiviral effects. The safety, tolerability pharmacokinetic (PK) profile of forsythin were evaluated in healthy Chinese subjects.