Comparative analysis of preventive role of different probiotics and prebiotics against the markers of liver damage, oxidative stress markers and inflammatory markers in the non-alcoholic fatty liver disease induced rats

• DOI: 10.1080/10942912.2022.2144881
• Publication Date: 2022-11-17T06:32:32Z
• Authors: Tayyab Shahzad; Sanaullah Iqbal; Muhammad Nasir; Aftab Ahmad Anjum; Muhammad Imran; Farhan Saeed; Mohamad Fawzi Mah...; Tahir Mehmood; Gokhan Zengin; Zarina Mushtaq; Muzzamal Hussain; Entessar Al Jbawi
• Keywords: Liver function

The current research was conducted to investigate and compare the role of functional foods such as probiotics prebiotics alone or in combinations on markers liver damage, oxidative stress inflammatory nonalcoholic fatty disease (NAFLD) induced rats. According results, G3, G4 G6 gained significant weight at end study. Moreover, weights different organs (liver, Spleen kidney) revealed that G1 (control negative) fed a standard diet lowest weight, G2 positive) high fat (HFD) maximum (9.63 ± 0.46 g). In addition, symbiotic group (G8) lowered organ (6.77 0.20 g), indicating HFD deposition body other organs. Furthermore, results serum function were concerned, Maximum reduction Alanine aminotransferase (ALT) found among G8 (Probiotics, GOS Inulin) (GOS). Aspartate (AST) significantly reduced all treatments compared control positive. Alkaline phosphate (ALP) G5, G7. Gamma-glutamyl transferase (GGT) remained unaffected during trial. As far tumor necrotic factor (TNF) groups had levels TNF after 19 weeks Upon therapy, strong association with hepatic inflammation various degrees portal (Chi-square value = 49.04**; P-value 0.000; ** Highly (P < .01). Overall histopathological analysis vacuoles treatment hepatocytes. progression fibrosis also groups. Conclusively, biomarkers NAFLD