Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imagingin vivo

• DOI: 10.1080/13102818.2014.984894
• Publication Date: 2014-11-26T11:30:59Z
• Authors: Rumiana Bakalova; Desislava Lazarova; Biliana Nikolova; Severina Atanasova; Genoveva Zlateva; Zhivko Zhelev; Ichio Aoki
• Keywords: Polymersome; Ex vivo

The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically modified chitosan, are appropriate for passive tumour targeting in the context of their application as drug carriers. experiments were performed colon cancer-grafted mice. mice subjected anaesthesia and injected intravenously with water-soluble nanoparticles: (1) QD705-labelled polymersomes (average size ∼120 nm; distribution ∼10%) or (2) native QD705. optical imaging carried out Maestro EX 2.10 In Vivo Imaging System (excitation filter 435-480 emission 700 nm, longpass). case QD705, fluorescence appeared area within 1 min after injection disappeared completely 60 min. A strong fluorescent signal detected liver 30th minute. visualization using QD705 only angiogenesis. polymersomes, immediately excellent blood vessels whole body. 16 hours. This indicated that delivered predominantly into due long circulation bloodstream enhanced permeability retention effect. very weak found area. data suggest size-controlled long-circulating promising carriers delivery solid tumours, including small nanoparticles contrast substances.