Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate

• DOI: 10.1080/17435889.2024.2347197
• Publication Date: 2024-05-30T12:56:43Z
• Authors: Lei He; Cheng Jiang; Jing Ren; Xiaoling Pan; Zhiwen Qiu; Yening Xia; Tian Wang; Jiahao Guo; Junfang Li; Wei Li
• Keywords: Biocompatibility

Aim: To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy. Materials & methods: Two series of polymer micelles, PEG-b-PCLm and PEG-b-PCLm/TPGS, were synthesized. Doxorubicin (DOX) loading into the micelles was achieved via solvent dialysis. Results: The displayed excellent biocompatibility, narrow size distribution, uniform morphology. DOX-loaded exhibited antitumor increased drug accumulation at tumor sites compared with free DOX. Additionally, 4A-PEG47-b-PCL21/TPGS effectively suppressed drug-resistant MCF-7/ADR cells. Conclusion: This study introduces novel micelle formulation exceptional serum stability against resistance, promising It highlights innovative strategies refining clinical translation ensuring sustained safety vivo.