eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production

• DOI: 10.1080/19491034.2024.2360196
• Publication Date: 2024-06-17T04:23:49Z
• Authors: Jean-Clément Mars; Biljana Culjkovic...; Katherine L.B. Bo...
• Keywords: EIF4E

The eukaryotic translation initiation factor eIF4E acts as a multifunctional that simultaneously influences mRNA processing, export, and in many organisms. Its multifactorial effects are derived from its capacity to bind the methyl-7-guanosine cap on 5'end of mRNAs thus can act chaperone for transcripts nucleus cytoplasm. In this review, we describe roles major mRNA-processing events including capping, splicing, cleavage polyadenylation, nuclear export translation. We discuss evidence at two levels generate widescale changes ultimately protein produced. First, alters production components processing machinery, supporting reprogramming multiple events. way, modulate without physically interacting with target transcripts. Second, also interacts both capped RNA or machineries. Further, specific sensitive only particular This selectivity is governed by presence cis-acting elements within known USER codes recruit relevant co-factors engaging appropriate machinery. all, molecular bases eIF4E's function regulatory pathways, basis selectivity, present compendium ~80 eIF4E-interacting factors which play these activities provide an overview relevance functions oncogenic potential. Finally, summarize early-stage clinical studies targeting cancer.